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. 2022 Jul 8;5(3):177–191. doi: 10.1093/abt/tbac015

Figure 8.

Figure 8

Analysis of long-term persistent antibody forming responses in the bone marrow of immunized mice. Mice were immunized as follows: Group 1 prime and homologous boost 45 μg rS1 WT. Group 2 prime and homologous boost 45 μg rS1 B.1.351. Group 5 prime 1 × 1010 v.p. Ad5.S1N and heterologous boost 45 μg rS1 WT. Group 6 prime 1 × 1010 v.p. Ad5.S1N and heterologous boost 45 μg rS1 B.1.351. Mice injected with PBS only served as negative controls. 29 weeks after immunization, S1-specific and N-specific antibody-forming cells in the bone marrow of mice were analyzed using ELISpot. (A) Quantification of SARS-CoV-2 S1-specific antibody forming cells in the bone marrow of immunized mice. (B) Quantification of SARS-CoV-2 N-specific antibody forming cells in the bone marrow of immunized mice. Data are from a single experiment (n = 5 per group). This experiment was conducted once.