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. 2022 Aug 11;140(9):880–884. doi: 10.1001/jamaophthalmol.2022.3026

Table 1. Characteristics of Tamoxifen and Docetaxel/Paclitaxel Users.

Characteristic Tamoxifen Docetaxel/paclitaxel
Epiphora
No. 16 395 1824
Age, y, mean (SD) 54.6 (12.8) 62.1 (12.7)
Follow-up, y, mean (SD) 3.5 (3.1) 2.0 (1.9)
Events, No. 45 20
Rate 7.9/10 000 person years 55.6/10 000 person years
Keratoconjunctivitis, % 0.05 0.11
Dry eye syndrome, % 0.29 2.25
Keratitis, % 2.07 3.95
Blepharitis, % 2.16 4.61
Eyelid malposition, % 0.55 1.35
Cystoid macular edema
No. 16 524 1909
Age, y, mean (SD) 54.6 (12.8) 62.5 (12.8)
Follow-up, y, mean (SD) 3.5 (3.1) 2.0 (1.9)
Events, No. 96 13
Rate 16.8/10 000 person years 34.8/10 000 person years
Cataract, % 0.6 2.1
Diabetes, % 8.0 14.3
Optic neuropathy
No. 16 395 1824
Age, y, mean (SD) 54.6 (12.8) 62.5 (12.8)
Follow-up, y, mean (SD) 3.5 (3.1) 2.0 (1.9)
Events, No. 7 4
Rate 1.2/10 000 person years 10.6/10 000 person years
Hypertension, % 6.0 38.2
Diabetes, % 9.9 17.4
Coronary artery disease, % 5.7 18.6