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. 2022 Aug 12;5:808. doi: 10.1038/s42003-022-03766-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, b t-SNE plot of scRNAseq data for a all samples or b faceted by condition. Cells are colored by cluster (k-means, n = 9), and clusters are labeled by cell type. c Bar plot showing the fraction of cells within the APC (top) and granulocyte (bottom) clusters. d, e Volcano plot showing differentially expressed genes in SARS-CoV-2-infected cells treated with WX8 versus untreated cells in the d granulocyte and e APC clusters. ISGs and genes in the interferon signaling pathway are colored blue (and labeled where space allows). TLRs in (e) are colored red. APC, antigen-presenting cells; Epith., epithelial cells.