Pharmacokinetic properties of the bioactive compounds isolated from BRBE.

Ligands	Absorption			Distribution			Metabolism		Excretion		Toxicity
	Caco-2 permeability	Intestinal absorption	Water solubility	VDss	BBB permeability	CNS permeability	Cytochrome P450 inhibitors	CYP2D6/CYP3A4 substrate	Renal OCT2 substrate	Total clearance	Rat LD50	Max. tolerated dose	Hepatotoxicity
COG	0.058	45.392	−2.929	1.464	−1.713	−3.813	No	No	No	0.522	2.549	0.562	No
FLS	−0.478	29.911	−1.863	−0.186	−1.358	−4.977	No	No	No	0.715	2.505	0.174	No
PCA	0.49	71.174	−2.069	−1.298	−0.683	−3.305	No	No	No	0.551	2.423	0.814	No
SPA	0.272	93.064	−2.869	−1.11	−0.247	−2.663	No	No	No	0.718	2.24	1.193	No
SYA	0.495	73.076	−2.223	−1.443	−0.191	−2.701	No	No	No	0.646	2.157	1.374	No
pCmA	1.21	93.494	−2.378	−1.151	−0.225	−2.418	No	No	No	0.662	2.155	1.111	No