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. 2022 Jul 29;9:943068. doi: 10.3389/fcvm.2022.943068

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Copyright © 2022 Pizzino, Furini, Casieri, Mariani, Bianchi, Storti, Chiappino, Maffei, Solinas, Aquaro and Lionetti.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diagnostic efficacy of pEXOs levels and exosomal miR-1, miR-21-5p, and miR-133a. The pEXOs were isolated from plasma of MR patients (n = 19) collected before (T0) and 6 months after MVR surgery (T1). (A) Isolated pEXOs were quantified by NTA as described in the methods. (B–D) Exosomal miRNA-1 (B), miRNA-21-5p (C) and miRNA-133a (D) were quantified through qRT-PCR as described in the method. Patients were divided into HiR-REM and LoR-REM groups. The diagnostic efficiency of T0, T1, and %Δ levels of pEXOs (particles/uL) (A) and of the microRNAs miR-1 (B), miR-21-5p (C) and miR-133a (D) (2^–ΔΔCT) in distinguishing patients with Low and High postoperative reverse LV remodeling was evaluated by the receiver operating characteristic (ROC) curve analysis as described in the methods. The AUC quantification and statistical significance (p-value) are reported in the table (E).