Table 1.
The effect of Lab4P supplementation on organ weights and plasma lipid profile in LDLr−/– mice fed HFD
| Control | Lab4P | p Value | |
|---|---|---|---|
| Mouse weight [g] | 35.9 ± 1.4 | 36.6 ± 1.5 | 0.764 |
| Weight gain [g] | 12.5 ± 1.6 | 11.7 ± 1.4 | 0.715 |
| Subcutaneous fat weight [g] | 1.39 ± 0.24 | 1.33 ± 0.22 | 0.853 |
| Gonadal fat weight [g] | 1.73 ± 0.26 | 1.67 ± 0.25 | 0.875 |
| Liver weight [mg] | 145.5 ± 6.6 | 147.5 ± 7.9 | 0.842 |
| Spleen weight [mg] | 110.8 ± 3.1 | 125.4 ± 5.7 | 0.034 |
| Heart weight [mg] | 181.5 ± 5.2 | 185.0 ± 3.9 | 0.594 |
| Thymus weight [mg] | 47.3 ± 3.7 | 50.0 ± 4.0 | 0.630 |
| LDL/VLDL [mg dL‐1] | 921.8 ± 62.4 | 743.3 ± 59.6 | 0.048 |
| HDL [mg dL‐1] | 128.9 ± 11.1 | 169.9 ± 15.1 | 0.039 |
| TC [mg dL‐1] | 1993 ± 68 | 2159 ± 94 | 0.161 |
| FC [mg dL‐1] | 633.9 ± 48.1 | 708.2 ± 49.3 | 0.301 |
| CE [mg dL‐1] | 1272 ± 106.8 | 1386 ± 89.3 | 0.423 |
| TG [mg dL‐1] | 339.6 ± 28.2 | 446.0 ± 32.2 | 0.019 |
| LDL/VLDL:HDL | 7.5 ± 0.6 | 4.5 ± 0.5 | 0.002 |
| TC:HDL | 17.6 ± 1.5 | 12.9 ± 1.2 | 0.031 |
| TC:LDL/VLDL | 2.2 ± 0.2 | 2.9 ± 0.3 | 0.044 |
Data represents the mean ± SEM from 30 mice (control n = 15; Lab4P n = 15). Statistical analysis was performed using an unpaired Student's t‐test. Values of p are stated and considered significant when p ≤ 0.05.
Abbreviations: CE, cholesterol esters; FC, free cholesterol; HDL, high‐density lipoprotein; LDL, low‐density lipoprotein; TC, total cholesterol; TG, triglycerides; VLDL, very low‐density lipoprotein.