Table 4.

Pharmacokinetics properties of some phytochemicals from flavonoid-rich extract of Dalbergiella welwitschii leaf.

Compounds	GI absorption	BBB permeant	P-gp substrate	CYP1A2 inhibitor	CYP2C19 inhibitor	CYP2C9 inhibitor	CYP2D6 inhibitor	CYP3A4 inhibitor	Log Kp (skin permeation) (cm/s)
Ellagic acid	High	No	No	Yes	No	No	No	No	−7.36
Piperine	High	Yes	No	Yes	Yes	Yes	No	No	−5.58
Gallic acid	High	No	No	No	No	No	No	Yes	−6.84
Caffeine	High	No	No	No	No	No	No	No	−7.53