Table 1.
Demographic profile and baseline clinical characteristics.
| Characteristics | Vaccination status (paired analysis) | Type of vaccine | No. of vaccine doses | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Vaccinated (N = 105) | Unvaccinated (N = 105) | p value | ChAdOx1 nCoV-19 (N = 47) | BBV152 (N = 58) | p value | One dose (N = 73) | Two doses (N = 32) | p value | ||
| Age, years (M ± SD) | 59.5 ± 13.9 | 59.8 ± 14.4 | 0.35 | 61.5 ± 12.4 | 57.9 ± 14.9 | 0.18 | 57.6 ± 13.3 | 63.7 ± 14.6 | 0.05 | |
| Male, N (%) | 70 (66.7) | 70 (66.7) | 1 | 31 (66) | 39 (67.2) | 0.89 | 49 (67.1) | 21 (65.6) | 0.88 | |
| Baseline severity, N (%) | MildModerateSevere | 46 (43.8)36 (34.3)23 (21.9) | 46 (43.8)36 (34.3)23 (21.9) | 1 | 19 (40.4)19 (40.4)9 (19.1) | 27 (66.6)17 (29.3)14 (24.1) | 0.48 | 31 (42.5)29 (39.7)13 (17.8) | 15 (46.9)7 (21.9)10 (31.3) | 0.14 |
| Severity progression, N (%) | 19 (18.1) | 8 (17) | 11 (19) | 0.8 | 11 (15.1) | 8 (25) | 0.22 | |||
| Maximum severity, N (%) | MildModerateSevere | 38 (36.2)33 (31.4)34 (32.4) | 16 (34)17 (36.2)14 (29.8) | 22 (37.9)16 (27.6)20 (34.5) | 0.64 | 28 (38.4)24 (32.9)21 (28.8) | 10 (31.3)9 (28.1)13 (40.6) | 0.49 | ||
| Median duration between symptom onset to hospitalization, days (IQR) | 5 (3–9) | 7 (3–9) | 1 | 6 | 5 | 0.15 | 5 | 7 | 0.47 | |
| Median days of symptom onset post-vaccination (IQR), days | 15 (7–28) | 17 | 14 | 0.29 | 15 | 17 | 0.93 | |||
| Comorbidities, N (%) | ||||||||||
| Diabetes mellitus | 39 (37.1) | 47 (44.8) | 0.10 | 18 (38.3) | 21 (36.2) | 0.83 | 27 (37) | 12 (37.5) | 0.96 | |
| Hypertension | 47 (44.8) | 46 (43.8) | 1 | 20 (42.6) | 27 (46.6) | 0.68 | 30 (41.1) | 17 (53.1) | 0.25 | |
| Chronic kidney disease | 4 (3.8) | 6 (5.7) | 0.69 | 3 (6.4) | 1 (1.7) | 0.32 | 4 (5.5) | 0 | 0.31 | |
| Coronary artery disease | 14 (13.3) | 20 (19) | 0.21 | 10 (21.3) | 4 (6.9) | 0.04 | 10 (13.7) | 4 (12.5) | 1 | |
| Chronic liver disease | 3 (2.9) | 1 (1) | 0.63 | 0 | 3 (5.2) | 0.25 | 1 (1.4) | 2 (6.3) | 0.22 | |
| Cerebrovascular disease | 4 (3.8) | 2 (1.9) | 0.69 | 0 | 4 (6.9) | 0.13 | 3 (4.1) | 1 (3.1) | 1 | |
| Chronic obstructive pulmonary disease | 4 (3.8) | 3 (2.9) | 1 | 2 (4.3) | 2 (3.4) | 1 | 2 (2.7) | 2 (6.3) | 0.58 | |
| Bronchial asthma | 5 (4.8) | 2 (1.9) | 0.38 | 4 (8.5) | 1 (1.7) | 0.17 | 3 (4.1) | 2 (6.3) | 0.64 | |
| Malignancy | 4 (3.8) | 2 (1.9) | 0.63 | 2 (4.3) | 2 (3.4) | 1 | 0 | 4 (12.5) | 0.008 | |
| Rheumatological disorder | 2 (1.9) | 1 (1) | 1 | 2 (4.3) | 0 | 0.2 | 2 (2.7) | 0 | 1 | |
| Hypothyroidism | 12 (11.4) | 5 (4.8) | 0.14 | 6 (12.8) | 6 (10.3) | 0.76 | 6 (8.2) | 6 (18.8) | 0.12 | |
| Clinical features, N (%) | ||||||||||
| Fever | 79 (75.2) | 78 (74.3) | 1 | 34 (72.3) | 45 (77.6) | 0.54 | 56 (76.7) | 23 (71.9) | 0.60 | |
| Cough | 72 (68.6) | 59 (56.2) | 0.07 | 36 (76.6) | 36 (62.1) | 0.11 | 50 (68.5) | 22 (68.8) | 0.98 | |
| Breathlessness | 47 (44.8) | 54 (51.4) | 0.32 | 21 (44.7) | 26 (44.8) | 0.99 | 34 (46.6) | 13 (40.6) | 0.57 | |
| Vitals, M ± SD | ||||||||||
| Pulse rate (bpm) | 87 ± 16 | 88 ± 11 | 0.70 | 89 ± 14 | 85 ± 17 | 0.17 | 87 ± 13 | 86 ± 21 | 0.85 | |
| Mean arterial pressure (mmHg) | 93 ± 10 | 95 ± 9 | 0.32 | 93 ± 10 | 93 ± 10 | 0.95 | 94 ± 10 | 93 ± 9 | 0.52 | |
| Respiratory rate (cpm) | 22 ± 5 | 23 ± 5 | 0.1 | 23 ± 6 | 22 ± 5 | 0.62 | 22 ± 6 | 22 ± 5 | 0.92 | |
| Oxygen saturation (%) | 92 ± 5 | 92 ± 6 | 0.44 | 92 ± 5 | 92 ± 5 | 0.62 | 92 ± 4 | 91 ± 7 | 0.32 | |
bpm, beats per minute; mmHg, millimeter of mercury; cpm, cycles per minute; IQR, Inter-quartile range; M, Mean; SD, Standard deviation.