Table 2.

Lowest P Values for Genetic Association With Between-Subject Variability in Plasma Bedaquiline Clearance in 140 PROBeX Participants

Polymorphism	Gene	Chromosome	Reference Allele	Variant Allele	MAF	β Value	P Value
PharmGKB and GWAS Catalog (n = 21)a
rs776746	CYP3A5	7	T	C	0.17	−.18	.0017
rs8050894	VKORC1	16	C	G	0.23	.11	.033
rs1800629	TNF	6	G	A	0.14	.11	.068
rs17782313	MC4R	18	T	C	0.24	−.09	.073
rs12979860	IFNL4	19	T	C	0.47	.04	.335
PharmGKB, not GWAS Catalog (n = 36)a
rs11615	ERCC1	19	G	A	0.13	.12	.08
rs2359612	VKORC1	16	G	A	0.26	−.07	.14
rs7997012	HTR2A	13	G	A	0.05	− .11	.23
rs1045642	ABCB1	7	G	A	0.16	−.07	.24
rs2298383	ADORA2A	22	C	T	0.38	−.05	.27
GWAS Catalog (n = 63 502)a
rs7977247	RIC8B	12	C	T	0.43	−.18	1.1 × 10−6
rs10778495	RFX4	12	G	A	0.47	−.19	1.7 × 10−6
rs10161520	RFX4	12	T	C	0.49	.17	1.2 × 10−5
rs11113071	RFX4	12	T	C	0.45	.17	1.2 × 10−5
rs10861637	RFX4	12	A	G	0.28	.19	1.3 × 10−5
Genome-wide genotype datab (n = 9 074 402)a
rs763450	RFX4	12	A	G	0.49	.20	6.4 × 10−7
rs78277930	Intergenic	9	A	T	0.05	−.46	6.6 × 10−7
rs80098193	Intergenic	9	A	G	0.05	−.46	6.6 × 10−7
rs114384536	Intergenic	9	C	A	0.05	−.46	6.6 × 10−7
rs12310706	RFX4	12	G	A	0.45	−.19	7.0 × 10−7

Abbreviations: MAF, minor allele frequency; PROBeX, Pharmacokinetics, Resistance, and Outcomes of Bedaquiline in MDR- and XDR-TB.

Parenthetical numbers are numbers of polymorphisms.

All polymorphisms with P values <1.0 × 10⁻⁶ are shown.