Table 3.

Lowest P Values for Genetic Association With Unexplained Variability in Plasma Clofazimine Clearance in 136 PROBeX Participants

Polymorphism	Gene	Chromosome	Reference Allele	Variant Allele	MAF	β Value	P Value
PharmGKB and GWAS Catalog (n = 21)a
rs9923231	VKORC1	16	C	T	0.07	−.11	.13
rs887829	UGT1A10	2	C	T	0.37	−.05	.17
rs8099917	Intergenic	19	T	G	0.07	.09	.21
rs489693	Intergenic	18	A	C	0.47	−.04	.23
rs1800629	TNF	6	G	A	0.14	.06	.24
PharmGKB, not GWAS Catalog (n = 36)a
rs11881222	IFNL3	19	A	G	0.34	.07	.047
rs2359612	VKORC1	16	G	A	0.25	−.07	.058
rs1042713	ADRB2	5	G	A	0.42	.06	.083
rs2740574	LOC110366354	7	C	T	0.29	−.06	.115
rs9934438	VKORC1	16	G	A	0.07	−.11	.126
GWAS Catalog (n = 63 502)a
rs3827592	Intergenic	4	G	A	0.29	−.17	1.73 × 10−5
rs7689452	Intergenic	4	A	G	0.29	−.17	1.96 × 10−5
rs79709502	LINC01800	2	C	G	0.20	.19	2.84 × 10−5
rs5749446	FBXO7	22	T	C	0.37	−.16	3.21 × 10−5
rs3827335	FBXO7	22	A	G	0.38	−.16	3.64 × 10−5
Genome-wide genotype datab (n = 9 074 402)a
rs75285763	CNTN5	11	A	G	0.04	.46	2.87 × 10−8
rs35274012	Intergenic	1	G	A	0.16	.25	1.05 × 10−7
rs562673502c	Intergenic	16	C	A	0.05	.39	6.05 × 10−7
rs147293114	NPAS3	14	TTTAG	T	0.05	.40	8.47 × 10−7
rs140444407	Intergenic	14	C	T	0.06	−.35	9.62 × 10−7
rs11769507	Intergenic	7	C	T	0.15	.23	9.910 × 10−7

Abbreviations: MAF, minor allele frequency; PROBeX, Pharmacokinetics, Resistance, and Outcomes of Bedaquiline in MDR- and XDR-TB.

Parenthetical numbers are numbers of polymorphisms.

All polymorphisms with P < 1.0 × 10⁻⁶ are shown.

Polymorphism rs562673502 was in complete linkage with rs534375032, rs147681927, rs569881175, rs148413871, rs141244461, and rs141114616 in our imputed genotype data, so it has identical association results.