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. 2022 Aug 12;28:95. doi: 10.1186/s10020-022-00525-1

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Fig. 5 — HIF-1α promoted macrophage glycolysis. Macrophages were transfected with HIF-1α siRNA: A mRNA levels of GLUT1, HK2, LDHA, IL1β and TGF-β1 (n = 3); B, C protein levels of HK2 and LDHA (n = 4); D amount of lactate in the macrophage supernatant (n = 3); *p < 0.05 vs. the Si-NC group. Macrophages were treated with FG-4592: E mRNA levels of GLUT1, HK2, LDHA, IL1β and TGF-β1 (n = 3); F, G protein levels of HK2 and LDHA (n = 4); H amount of lactate in the macrophage supernatant (n = 3); *p < 0.05 vs. the Control group