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. 2022 Aug 12;20:365. doi: 10.1186/s12967-022-03567-5

Fig.2.

Fig.2

Dynamic change of genomic features in ctDNA correlated with clinical efficacy during chemotherapy. A: values of CCF, TMB, CNI and CNV burden at baseline (BL), progressive disease (PD) and during treatment (PR, SD). B: correlation between ΔTMB of ctDNA and patients’ outcomes of first-line therapy. C: dynamic changes of genomic features in ctDNA and tumor volumes in three typical cases