Table 1.

Examples of scenarios compatible with systemic primary hyperfibrinolysis.

Systemic primary hyperfibrinolysis: imbalance between fibrinolytic system activators and inhibitors
Origin of imbalance	Compatible scenarios
Increased endothelial production of activators (usually caused by endothelial stress)	Catecholamine, angiotensin, and vasopressin secretion bursts: shock scenarios, vasoactive drug use, electrical discharge
	Scenarios with hypoxia, hypoperfusion or acidosis: shock, cardiopulmonary arrest, intraoperative vascular clamping/ kinking, tourniquets applied on limb, thromboembolic vascular occlusions, transplant surgery (grafts are ischemic until they are implanted)
Activators arising from non-endothelial origin	Use of fibrinolytic drugs
	Organs for transplants
	Solid tumors expressing t-PA or u-PA
Failure to clear fibrinolytic activators	Severe liver disease or decreased hepatic blood flow
	Anhepathic phase during liver transplantation
Reduction of fibrinolytic inhibitors level	Severe liver disease or decreased hepatic blood flow
	Anhepathic phase during liver transplantation
	Extracorporeal circulation
	Acute traumatic coagulopathy