Table 2.

Examples of scenarios compatible with systemic secondary hyperfibrinolysis.

Systemic secondary hyperfibrinolysis: clot weakening and exhaustion of fibrinolysis inhibitors after extreme and prolonged coagulation activation
Mechanism	Compatible scenarios
Coagulation is activated anomalously and dissociatedly from fibrinolysis (DIC)	Sepsis
	Tissue factor-expressing neoplasms (mucinous adenocarcinomas, malignant brain tumors and acute promyelocytic leukemia)
	Obstetric complications (retained products of conception, pre-eclampsia, amniotic embolism, placenta praevia)
Major tissue damage causing intense, sustained and orchestrated activation of coagulation and fibrinolysis	Major trauma
	Major non-cardiac surgeries
	Major cardiovascular surgeries
	Postpartum hemorrhage (placental abruption, uterine atony or rupture, placenta praevia, placenta accreta)