Table 3.

Examples of scenarios compatible with local hyperfibrinolysis.

Local hyperfibrinolysis: trauma or surgery on tissues rich in fibrinolytic activators (t-PA and u-PA), causing their local release
Tissues	Bleeding scenarios with potential contribution of local fibrinolysis
Vascular endothelium of leptomeninges and choroid plexus	Bleeding after subarachnoid hemorrhage
	Traumatic brain injury
	Meningioma surgery
Oral and nasal mucosae	Adenoidectomy
	Tonsillectomy
	Oral cavity surgery
	Rhinoplasty and other nasal endoscopic surgeries
	Tooth extraction in hemophiliac patients or with von Willebrand disease
Eyes (Schlemm's canal endothelium)	Traumatic hyphema
	Eye trauma
Mucosa of the esophagus and stomach	Upper gastrointestinal bleeding
Genito-urinary tract	Surgery on the prostate, uterus, ovary, and bladder
Rectal mucosa	Lower gastrointestinal bleeding in patients with Crohn's disease or ulcerative colitis