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. 2022 Jul 29;13:938075. doi: 10.3389/fimmu.2022.938075

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Copyright © 2022 Sebastian, Hum, McCool, Wilson, Murugesh, Martin, Rios-Arce, Amiri, Christiansen and Loots

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Injury-induced changes in the localization of Lyve1^hiFolr2^hi macrophages based on Lyve1 expression. (A) IHC showing Lyve1 and Trem2 expression in macrophages at D0, D7 and D30 (20× magnification; scale bar = 200μm), and a closer view of the images for (B) D0, (C) D7 and (D) D30 matching to the highlighted boxes in A (scale bar = 25μm). The Lyve1⁺ macrophages were primarily observed at the synovial lining at D0. The lining of Lyve1⁺ macrophages was disrupted after injury and these cells started to infiltrate the synovial membrane. Ca, cartilage; Syn, synovium.