Table 4.

Comparison between the advantages and disadvantages of intramuscular (IM) injection route and other related parenteral dosage forms.

Intramuscular (IM) Injection Route
Advantages	Disadvantages
A faster rate of absorption compared to subcutaneous (SC) and intradermal (ID) injections	A slower rate of absorption compared to intravenous (IV) injection. However, risky compared to IV injections
Capable of absorbing larger volumes of solutions compared to SC, IV, and ID injections	General discomfort is expected, such as a painful sensation at the site of injection
The drug diffuses into the systematic circulation rapidly	Tingling and numbness sensations
Almost 100% bioavailability	Sometimes causes swollenness at the site of injection
It also avoids the gastric factors governing the drug absorption	The rate of administration at the site of injection will be slow to avoid injury to muscles