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. 2022 Aug 8;12(13):6021–6037. doi: 10.7150/thno.70448

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Retention of SILY-EVs in a mouse hind limb ischemia model. (A) Ex vivo evaluation for retention of EVs and SILY-EVs on the ischemic hind limb tissue section via binding to collagen. Green indicated collagen, blue indicated nucleus, red indicated DiD-labeled EVs, and gray indicated TAMRA-labeled SILY. The white arrows indicated EVs or SILY-EVs attached on the collagen of the ischemic hind limb tissue section. Scale bar = 10 μm. (B) Quantification of the EVs and SILY-EVs attached on the collagen of the ischemic hind limb tissue section. (C) Representative IVIS images of the retention of EVs or SILY-EVs at different time points after transplantation in the mouse hind limb ischemia model. (D) Quantification of the fluorescence intensity in EV group and SILY-EV group after transplantation in the mouse hind limb ischemia model. Data are expressed as mean ± standard deviation: **p < 0.01 (n = 6).