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. 2022 Aug 8;12(13):6021–6037. doi: 10.7150/thno.70448

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Effects of SILY-EVs on inflammatory response and macrophage polarization in the mouse ischemic hind limb. (A) Representative immunofluorescence staining of CCR7⁺ M1 macrophages, CD163⁺ M2 macrophages and CD68⁺ macrophages. Scale bar = 50 μm. Quantification of the number of (B) CD68⁺ macrophages, (C) CCR7⁺ M1 macrophages, (D) CD163⁺ M2 macrophages and (E) M2/M1 ratio in the ischemic hind limb. Gene expression of (F) IFN-γ and (G) IL10 in different treatment groups. Data are expressed as mean ± standard deviation: *p < 0.05, **p < 0.01 (n = 6).