Figure 3.

Proteomic bioprofiles of bronchial aspirates from survivors and nonsurvivors of ARDS secondary to SARS-CoV-2 infection. (A) Volcano plot showing the p value versus the fold change. Each point represents a detected protein. Blue dots represent the detected proteins that showed significant differences considering a p value<0.05. The association was adjusted by age. (B) Boxplot including bronchial aspirate proteins that showed differences between study groups. The adjusted fold change is displayed, and the significance level for each comparison is described by the p value. (C) Variable importance plot displaying the most relevant proteins according to their contribution to the random forest model. (D) Kaplan-Meier estimations for the individual proteins and BAS protein-based prediction model. Log-rank p values are displayed. (E) Cell enrichment analysis based on single-cell RNA-seq data from Genotype-Tissue Expression (GTex). Each row represents a protein, and each column represents a cell type. The color of the point shows the expression levels in detected cells, and the size of the point indicates the percentage of cells in which the expression was detected.