Table 1.
Characteristics of patients with non-COVID-19 and COVID-19 ARDS (study population 1).
| ALL | Non-COVID-19 | COVID-19 | p value | N | |
|---|---|---|---|---|---|
| N=74 | N=14 | N=60 | |||
| Sociodemographic characteristics | |||||
| Age (years) | 66.0 [59.0;71.0] | 66.5 [64.0;72.5] | 64.5 [59.0;71.0] | 0.243 | 74 |
| Female | 17 (23.0%) | 6 (42.9%) | 11 (18.3%) | 0.075 | 74 |
| Smoking history: | 0.163 | 70 | |||
| Current | 10 (14.3%) | 4 (30.8%) | 6 (10.5%) | ||
| Former | 30 (42.9%) | 4 (30.8%) | 26 (45.6%) | ||
| Nonsmoker | 30 (42.9%) | 5 (38.5%) | 25 (43.9%) | ||
| Comorbidities | |||||
| Hypertension | 42 (56.8%) | 7 (50.0%) | 35 (58.3%) | 0.789 | 74 |
| Diabetes mellitus | 29 (39.2%) | 4 (28.6%) | 25 (41.7%) | 0.549 | 74 |
| Obesity | 36 (48.6%) | 3 (21.4%) | 33 (55.0%) | 0.049 | 74 |
| Cardiovascular disease | 14 (18.9%) | 3 (21.4%) | 11 (18.3%) | 0.721 | 74 |
| Chronic lung disease | 12 (16.2%) | 7 (50.0%) | 5 (8.33%) | 0.001 | 74 |
| Asthma | 3 (4.05%) | 1 (7.14%) | 2 (3.33%) | 0.472 | 74 |
| Chronic kidney disease | 6 (8.11%) | 1 (7.14%) | 5 (8.33%) | 1.000 | 74 |
| ICU Admission | |||||
| Oxygen saturation (%) | 93.0 [88.0;95.2] | 93.0 [92.0;93.5] | 92.5 [88.0;95.2] | 0.919 | 67 |
| FiO2 (%) | 70.0 [50.0;90.0] | 50.0 [50.0;50.0] | 70.0 [50.0;90.0] | 0.350 | 53 |
| PaO2 (mm Hg) | 71.0 [55.8;96.2] | 122 [84.5;140] | 67.0 [52.8;83.0] | 0.001 | 60 |
| PaCO2 (mm Hg) | 37.0 [32.0;43.0] | 37.5 [34.0;44.0] | 37.0 [31.5;41.4] | 0.529 | 60 |
| Glucose (mg/dL) | 144 [115;207] | 128 [110;174] | 147 [116;215] | 0.320 | 74 |
| Creatinine (mg/dL) | 0.90 [0.71;1.13] | 0.83 [0.70;0.93] | 0.94 [0.72;1.13] | 0.423 | 73 |
| C-reactive protein (mg/dL) | 152 [86.0;224] | 138 [70.0;252] | 152 [86.0;216] | 0.976 | 66 |
| D-dimer (ng/mL) | 397 [316;843] | 475 [367;3883] | 397 [301;843] | 0.501 | 53 |
| Leukocyte count (x109/L) | 8.02 [6.47;12.4] | 11.0 [7.44;18.9] | 7.78 [6.40;10.5] | 0.087 | 74 |
| Neutrophil count (x109/L) | 6.68 [5.28;10.2] | 14.2 [5.48;18.8] | 6.39 [5.27;8.55] | 0.100 | 72 |
| Lymphocyte count (x109/L) | 0.83 [0.52;1.33] | 1.44 [1.05;1.87] | 0.66 [0.51;1.17] | 0.036 | 72 |
| Monocyte count (x109/L) | 0.40 [0.21;0.62] | 0.65 [0.50;0.97] | 0.36 [0.21;0.54] | 0.015 | 71 |
| Platelet count (x109/L) | 230 [188;279] | 218 [171;277] | 232 [188;279] | 0.571 | 74 |
| ICU Stay | |||||
| ICU stay (days) | 40.5 [16.2;58.0] | 8.50 [6.25;18.2] | 43.5 [30.5;61.5] | <0.001 | 74 |
| Noninvasive mechanical ventilation | 57 (78.1%) | 7 (53.8%) | 50 (83.3%) | 0.030 | 73 |
| Prone positioning | 58 (81.7%) | 2 (16.7%) | 56 (94.9%) | <0.001 | 71 |
| Treatments | |||||
| Antibiotics | 64 (86.5%) | 8 (57.1%) | 56 (93.3%) | 0.002 | 74 |
| Hydroxychloroquine | 23 (31.1%) | 3 (21.4%) | 20 (33.3%) | 0.527 | 74 |
| Tocilizumab | 43 (58.1%) | 2 (14.3%) | 41 (68.3%) | 0.001 | 74 |
| Interferon beta | 2 (2.70%) | 0 (0.00%) | 2 (3.33%) | 1.000 | 74 |
| Corticoids | 59 (79.7%) | 7 (50.0%) | 52 (86.7%) | 0.006 | 74 |
| Remdesivir | 13 (17.6%) | 0 (0.00%) | 13 (21.7%) | 0.111 | 74 |
Continuous variables are expressed as the median [P25;P75] and categorical variables as n (%). FiO2, fraction of inspired oxygen; ICU, Intensive care unit; PaCO2, carbon dioxide partial pressure; PaO2, oxygen partial pressure.