Table 2.
Characteristics of ICU COVID-19 survivors and nonsurvivors ARDS secondary to SARS-CoV-2 infection (study population 2).
| ALL | Survivors | Nonsurvivors | p value | N | |
|---|---|---|---|---|---|
| N=60 | N=43 | N=17 | |||
| Sociodemographic characteristics | |||||
| Age (years) | 64.5 [59.0;71.0] | 63.0 [57.0;70.0] | 67.0 [63.0;71.0] | 0.123 | 60 |
| Female | 11 (18.3%) | 8 (18.6%) | 3 (17.6%) | 1.000 | 60 |
| Smoking history: | 0.481 | 57 | |||
| Current | 6 (10.5%) | 3 (7.32%) | 3 (18.8%) | ||
| Former | 26 (45.6%) | 19 (46.3%) | 7 (43.8%) | ||
| Nonsmoker | 25 (43.9%) | 19 (46.3%) | 6 (37.5%) | ||
| Comorbidities | |||||
| Hypertension | 35 (58.3%) | 26 (60.5%) | 9 (52.9%) | 0.809 | 60 |
| Diabetes mellitus | 25 (41.7%) | 20 (46.5%) | 5 (29.4%) | 0.358 | 60 |
| Obesity | 33 (55.0%) | 23 (53.5%) | 10 (58.8%) | 0.931 | 60 |
| Cardiovascular disease | 11 (18.3%) | 7 (16.3%) | 4 (23.5%) | 0.712 | 60 |
| Chronic lung disease | 5 (8.33%) | 3 (6.98%) | 2 (11.8%) | 0.616 | 60 |
| Asthma | 2 (3.33%) | 2 (4.65%) | 0 (0.00%) | 1.000 | 60 |
| Chronic kidney disease | 5 (8.33%) | 4 (9.30%) | 1 (5.88%) | 1.000 | 60 |
| ICU admission | |||||
| Oxygen saturation (%) | 92.5 [88.0;95.2] | 92.0 [88.0;94.8] | 94.1 [91.0;96.0] | 0.114 | 58 |
| FiO2 (%) | 70.0 [50.0;90.0] | 60.0 [48.8;82.5] | 75.0 [60.0;90.0] | 0.202 | 48 |
| PaO2 (mm Hg) | 67.0 [52.8;83.0] | 65.0 [51.5;80.0] | 76.0 [56.0;83.0] | 0.501 | 48 |
| PaCO2 (mm Hg) | 37.0 [31.5;41.4] | 38.0 [34.0;41.6] | 32.0 [29.0;40.0] | 0.285 | 48 |
| Glucose (mg/dL) | 147 [116;215] | 164 [116;235] | 129 [121;156] | 0.082 | 60 |
| Creatinine (mg/dL) | 0.94 [0.72;1.13] | 0.93 [0.72;1.10] | 1.00 [0.69;1.13] | 0.857 | 60 |
| C-reactive protein (mg/L) | 152 [86.9;216] | 151 [86.9;192] | 161 [106;289] | 0.330 | 58 |
| D-dimer (ng/mL) | 397 [301;843] | 422 [323;1388] | 367 [285;432] | 0.138 | 49 |
| Leukocyte count (x109/L) | 7.78 [6.40;10.5] | 7.39 [6.28;9.94] | 8.61 [6.93;14.1] | 0.147 | 60 |
| Neutrophil count (x109/L) | 6.39 [5.27;8.55] | 6.32 [5.35;8.27] | 7.01 [4.92;9.41] | 0.604 | 59 |
| Lymphocyte count (x109/L) | 0.66 [0.51;1.17] | 0.64 [0.51;1.09] | 0.73 [0.51;2.14] | 0.273 | 59 |
| Monocyte count (x109/L) | 0.36 [0.21;0.54] | 0.34 [0.21;0.48] | 0.48 [0.21;0.56] | 0.203 | 59 |
| Platelet count (x109/L) | 232 [188;279] | 237 [202;276] | 203 [139;287] | 0.106 | 60 |
| ICU Stay | |||||
| ICU stay (days) | 43.5 [30.5;61.5] | 44.0 [25.5;62.0] | 41.0 [31.0;51.0] | 0.670 | 60 |
| Noninvasive mechanical ventilation | 50 (83.3%) | 37 (86.0%) | 13 (76.5%) | 0.448 | 60 |
| Prone positioning | 56 (94.9%) | 39 (92.9%) | 17 (100%) | 0.550 | 59 |
| Treatments | |||||
| Antibiotics | 56 (93.3%) | 40 (93.0%) | 16 (94.1%) | 1.000 | 60 |
| Hydroxychloroquine | 20 (33.3%) | 14 (32.6%) | 6 (35.3%) | 1.000 | 60 |
| Tocilizumab | 41 (68.3%) | 30 (69.8%) | 11 (64.7%) | 0.943 | 60 |
| Interferon beta | 2 (3.33%) | 2 (4.65%) | 0 (0.00%) | 1.000 | 60 |
| Corticoids | 52 (86.7%) | 36 (83.7%) | 16 (94.1%) | 0.420 | 60 |
| Remdesivir | 13 (21.7%) | 8 (18.6%) | 5 (29.4%) | 0.488 | 60 |
Continuous variables are expressed as the median [P25; P75] and categorical variables as n (%). FiO2, fraction of inspired oxygen; ICU, Intensive care unit; PaCO2, carbon dioxide partial pressure; PaO2, oxygen partial pressure.