Table 8.

Notable trends in select design characteristics (phase II and III protocols)

Means	2009–2012	2013–2016	2017–2020	Overall growth
Total Endpoints	16.6	17.2	21.1	27.1%
Total Eligibility Criteria	29.7	30.0	32.7	10.1%
Total Procedures Performed	159.7	186.9	267.1	67.3%
Percent of Total Non-Core Procedures	N/A	21.2%	24.7%	16.5%
Total Procedures per Patient Visit	11.3	12.4	13.8	22.1%
Total Countries	5.5	7.9	9.3	69.1%
Total Investigative Sites	43.6	58.3	58.0	33.0%