Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Aug 12;10:goac035. doi: 10.1093/gastro/goac035

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022. Published by Oxford University Press and Sixth Affiliated Hospital of Sun Yat-sen University

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 3. — Various factors contributing to DNA methylation alterations and linked to the risk for CRC development. Various physiological and environmental risk factors (e.g. microbiome, obesity and diet, inflammation, and aging) contribute to the early acquisition of epigenetic alterations over time, eventually leading to cancer initiation following genetic driver mutations. These factors together are linked to the various macro-environmental exposures that contribute to the age-related DNA methylation changes. CRC, colorectal cancer; TF, transcription factor.