Table 3.
Multiple Logistic Regression for the Association Between G-Allele Carriers and Heart Disease
| All Participants | Men | Women | ||||
|---|---|---|---|---|---|---|
| Risk Factors | OR (95% CI) | p* | OR (95% CI) | p* | OR (95% CI) | p* |
| Model 1a: FOXO3 G-allele carrier | 1.01 (0.79–1.30) | .918 | 0.74 (0.52–1.04) | .080 | 1.51 (1.04–2.19) | .030 |
| Model 2b: FOXO3 G-allele carrier | 1.02 (0.80–1.31) | .861 | ||||
| Model 3c: FOXO3 G-allele carrier | 0.99 (0.76–1.28) | .924 | 0.70 (0.49–0.99) | .046 | 1.52 (1.02–2.25) | .039 |
| Model 4d: FOXO3 G-allele carrier | 0.99 (0.76–1.29) | .958 | 0.70 (0.49–1.00) | .052 | 1.49 (1.00–2.21) | .049 |
| Women† | 0.74 (0.52–1.05) | .094 | ||||
| Age† | 1.52 (1.16–1.98) | .002 | 1.48 (1.04–2.12) | .031 | 1.60 (1.05–2.43) | .027 |
| Diabetes† | 1.21 (0.87–1.68) | .261 | 1.47 (0.98–2.21) | .066 | 0.83 (0.46–1.50) | .531 |
| Hypertension† | 1.55 (1.11–2.17) | .009 | 1.97 (1.23–3.18) | .005 | 1.23 (0.77–1.98) | .391 |
| Dyslipidemia† | 1.00 (1.00–1.00) | .907 | 1.00 (1.00–1.00) | .860 | 1.00 (1.00–1.00) | .883 |
| Smoking status, ever† | 1.35 (0.95–1.91) | .094 | 1.18 (0.79–1.77) | .417 | 1.82 (0.98–3.38) | .058 |
Notes: 95% CI = 95% confidence interval; OR = odds ratio; aAdjusting for age; bAdjusting for age and sex; cAdjusting for diabetes, hypertension, dyslipidemia, and smoking; dFor all participants, adjusting for sex, age, diabetes, hypertension, dyslipidemia, and smoking. For sex stratified, adjusting for age, diabetes, hypertension, dyslipidemia, and smoking; FOXO3 G-allele carrier indicates persons who had at least one G allele of FOXO3 SNP rs2802292. Shown are homozygotes (GG) and heterozygotes (TG) combined; TT genotype was used as the reference group for calculation of OR.
*p values based on logistic regression adjustment.
†From all adjusted models.