Table 2.
The Association Between FOXO3 SNPs and Mortality
| SNP | Minor Allele Number | Total | Male | Female | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| n | HR (95% CI) | p | n | HR (95% CI) | p | N | HR (95% CI) | p | ||
| rs4946936 | 0 | 1 715 | Reference | — | 788 | Reference | — | 927 | Reference | — |
| rs4946936 | 1 | 1 220 | 0.931 (0.849–1.022) | .13 | 585 | 0.981 (0.854–1.129) | .79 | 635 | 0.897 (0.792–1.016) | .087 |
| rs4946936 | 2 | 231 | 0.771 (0.645–0.922) | .004 | 114 | 0.912 (0.708–1.175) | .48 | 117 | 0.666 (0.517–0.858) | .0016 |
| rs2802292 | 0 | 1 590 | Reference | — | 733 | Reference | — | 857 | Reference | — |
| rs2802292 | 1 | 1 282 | 0.959 (0.874–1.052) | .38 | 602 | 0.96 (0.834–1.105) | .57 | 680 | 0.961 (0.849–1.088) | .53 |
| rs2802292 | 2 | 294 | 0.79 (0.672–0.928) | .004 | 152 | 0.949 (0.758–1.19) | .65 | 142 | 0.667 (0.528–0.843) | .00069 |
| rs2253310 | 0 | 1 609 | Reference | — | 739 | Reference | — | 870 | Reference | — |
| rs2253310 | 1 | 1 261 | 0.946 (0.862–1.039) | .25 | 595 | 0.967 (0.839–1.113) | .64 | 666 | 0.933 (0.824–1.057) | .28 |
| rs2253310 | 2 | 296 | 0.789 (0.671–0.926) | .004 | 153 | 0.948 (0.758–1.187) | .64 | 143 | 0.666 (0.528–0.84) | .00060 |
| rs4946936 | 0 | 1 715 | Reference | — | 788 | Reference | — | 927 | Reference | — |
| rs4946936 | 1/2 | 1 451 | 0.903 (0.826–0.987) | .025 | 699 | 0.969 (0.849–1.107) | .65 | 752 | 0.856 (0.76–0.965) | .011 |
| rs2802292 | 0 | 1 590 | Reference | — | 733 | Reference | — | 857 | Reference | — |
| rs2802292 | 1/2 | 1 576 | 0.924 (0.846–1.01) | .081 | 754 | 0.958 (0.838–1.094) | .52 | 822 | 0.901 (0.8–1.015) | .087 |
| rs2253310 | 0 | 1 609 | Reference | — | 739 | Reference | — | 870 | Reference | — |
| rs2253310 | 1/2 | 1 557 | 0.914 (0.836–0.998) | .045 | 748 | 0.963 (0.843–1.099) | .57 | 809 | 0.879 (0.78–0.99) | .034 |
| rs4946936 | 0/1 | 2 935 | Reference | — | 1 373 | Reference | — | 1 562 | Reference | — |
| rs4946936 | 2 | 231 | 0.795 (0.668–0.947) | .010 | 114 | 0.919 (0.719–1.176) | .50 | 117 | 0.698 (0.545–0.894) | .0044 |
| rs2802292 | 0/1 | 2 872 | Reference | — | 1 335 | Reference | — | 1 537 | Reference | — |
| rs2802292 | 2 | 294 | 0.805 (0.689–0.941) | .0066 | 152 | 0.967 (0.779–1.201) | .76 | 142 | 0.679 (0.542–0.852) | .00084 |
| rs2253310 | 0/1 | 2 870 | Reference | — | 1 334 | Reference | — | 1 536 | Reference | — |
| rs2253310 | 2 | 296 | 0.808 (0.692–0.944) | .0073 | 153 | 0.963 (0.776–1.194) | .73 | 143 | 0.687 (0.548–0.861) | .0011 |
| rs4946936 | 1 | 1 220 | Reference | — | 585 | Reference | — | 635 | Reference | — |
| rs4946936 | 0 | 1 715 | 1.074 (0.978–1.178) | .13 | 788 | 1.019 (0.886–1.172) | .79 | 927 | 1.115 (0.984–1.263) | .087 |
| rs4946936 | 2 | 231 | 0.828 (0.69–0.994) | .042 | 114 | 0.929 (0.717–1.204) | .58 | 117 | 0.743 (0.574–0.961) | .024 |
| rs2802292 | 1 | 1 282 | Reference | — | 602 | Reference | — | 680 | Reference | — |
| rs2802292 | 0 | 1 590 | 1.043 (0.95–1.145) | .38 | 733 | 1.042 (0.905–1.2) | .59 | 857 | 1.041 (0.919–1.178) | .53 |
| rs2802292 | 2 | 294 | 0.824 (0.699–0.971) | .021 | 152 | 0.989 (0.786–1.244) | .93 | 142 | 0.694 (0.548–0.88) | .0025 |
| rs2253310 | 1 | 1 261 | Reference | — | 595 | Reference | — | 666 | Reference | — |
| rs2253310 | 0 | 1 609 | 1.057 (0.963–1.16) | .25 | 739 | 1.035 (0.898–1.191) | .64 | 870 | 1.071 (0.946–1.213) | .28 |
| rs2253310 | 2 | 296 | 0.833 (0.707–0.982) | .029 | 153 | 0.981 (0.78–1.233) | .87 | 143 | 0.714 (0.564–0.904) | .0051 |
Notes: SNP = single-nucleotide polymorphism; HR = hazard ratio; CI = confidence interval. All models adjusted for baseline age and sex.