Table 3.

The Association Between SIRT1 SNPs and Mortality

SNP	Minor Allele Number	Total			Male			Female
		n	HR (95% CI)	p	n	HR (95% CI)	p	n	HR (95% CI)	p
rs12778366	0	2 334	Reference	—	1 090	Reference	—	1 244	Reference	—
rs12778366	1	761	1.046 (0.943–1.161)	.39	363	1.088 (0.934–1.268)	.28	398	1.008 (0.875–1.162)	.91
rs12778366	2	71	1.071 (0.772–1.486)	.68	34	1.202 (0.752–1.921)	.44	37	0.963 (0.609–1.522)	.87
rs3758391	0	2 231	Reference	—	1 041	Reference	—	1 190	Reference	—
rs3758391	1	855	1.054 (0.956–1.162)	.29	412	1.149 (0.993–1.328)	.061	443	0.987 (0.865–1.127)	.85
rs3758391	2	80	0.776 (0.571–1.056)	.11	34	0.591 (0.341–1.025)	.061	46	0.907 (0.626–1.315)	.61
rs2273773	0	1 693	Reference	—	792	Reference	—	901	Reference	—
rs2273773	1	1 246	1.083 (0.987–1.188)	.091	587	1.113 (0.969–1.278)	.13	659	1.06 (0.936–1.201)	.38
rs2273773	2	227	0.986 (0.827–1.175)	.87	108	0.929 (0.709–1.216)	.59	119	1.034 (0.82–1.305)	.78
rs4746720	0	1 039	Reference	—	483	Reference	—	556	Reference	—
rs4746720	1	1 550	1.064 (0.963–1.175)	.22	754	1.012 (0.873–1.173)	.88	796	1.109 (0.97–1.268)	.13
rs4746720	2	577	0.911 (0.799–1.039)	.16	250	0.847 (0.69–1.04)	.11	327	0.959 (0.809–1.138)	.63
rs12778366	0	2 334	Reference	—	1 090	Reference	—	1 244	Reference	—
rs12778366	1/2	832	1.048 (0.947–1.16)	.36	397	1.096 (0.945–1.272)	.23	435	1.005 (0.875–1.154)	.94
rs3758391	0	2 231	Reference	—	1 041	Reference	—	1 190	Reference	—
rs3758391	1/2	935	1.029 (0.935–1.132)	.56	446	1.1 (0.953–1.268)	.19	489	0.98 (0.862–1.114)	.76
rs2273773	0	1 693	Reference	—	792	Reference	—	901	Reference	—
rs2273773	1/2	1 473	1.067 (0.977–1.166)	.15	695	1.082 (0.948–1.236)	.24	778	1.056 (0.938–1.189)	.37
rs4746720	0	1 039	Reference	—	483	Reference	—	556	Reference	—
rs4746720	1/2	2 127	1.019 (0.928–1.12)	.69	1 004	0.969 (0.841–1.115)	.66	1 123	1.062 (0.936–1.204)	.35
rs12778366	0/1	3 095	Reference	—	1 453	Reference	—	1 642	Reference	—
rs12778366	2	71	1.059 (0.764–1.468)	.73	34	1.176 (0.737–1.877)	.50	37	0.961 (0.609–1.516)	.86
rs3758391	0/1	3 086	Reference	—	1 453	Reference	—	1 633	Reference	—
rs3758391	2	80	0.765 (0.563–1.038)	.085	34	0.568 (0.328–0.983)	.043	46	0.911 (0.63–1.318)	.62
rs2273773	0/1	2 939	Reference	—	1 379	Reference	—	1 560	Reference	—
rs2273773	2	227	0.953 (0.803–1.131)	.58	108	0.887 (0.682–1.153)	.37	119	1.009 (0.805–1.266)	.93
rs4746720	0/1	2 589	Reference	—	1 237	Reference	—	1 352	Reference	—
rs4746720	2	577	0.879 (0.782–0.988)	.030	250	0.841 (0.699–1.011)	.066	327	0.904 (0.777–1.051)	.19
rs12778366	1	761	Reference	—	363	Reference	—	398	Reference	—
rs12778366	0	2 334	0.956 (0.861–1.06)	.39	1 090	0.919 (0.788–1.071)	.28	1 244	0.992 (0.861–1.143)	.91
rs12778366	2	71	1.023 (0.732–1.431)	.89	34	1.104 (0.683–1.786)	.69	37	0.955 (0.598–1.526)	.85
rs3758391	1	855	Reference	—	412	Reference	—	443	Reference	—
rs3758391	0	2 231	0.949 (0.86–1.046)	.29	1 041	0.871 (0.753–1.007)	.061	1 190	1.013 (0.887–1.157)	.85
rs3758391	2	80	0.737 (0.538–1.008)	.056	34	0.515 (0.295–0.899)	.020	46	0.919 (0.628–1.345)	.66
rs2273773	1	1 246	Reference	—	587	Reference	—	659	Reference	—
rs2273773	0	1 693	0.923 (0.842–1.013)	.091	792	0.899 (0.783–1.032)	.13	901	0.943 (0.833–1.068)	.36
rs2273773	2	227	0.91 (0.761–1.089)	.30	108	0.835 (0.635–1.097)	.19	119	0.976 (0.769–1.237)	.84
rs4746720	1	1 550	Reference	—	754	Reference	—	796	Reference	—
rs4746720	0	1 039	0.94 (0.851–1.038)	.22	483	0.988 (0.853–1.146)	.88	556	0.902 (0.789–1.031)	.13
rs4746720	2	577	0.857 (0.757–0.969)	.014	250	0.837 (0.69–1.016)	.072	327	0.865 (0.737–1.016)	.078

Notes: SNP = single-nucleotide polymorphism; HR = hazard ratio; CI = confidence interval. All models adjusted for baseline age and sex.