Table 2.
The Association Between FOXO3 SNPs, Residence, and Mortality
| Term | Model—Residence | Model—FOXO | Model—FOXO + Residence | Model—FOXO × Residence | |||||
|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | β (SE) | p | |
| FOXO3_rs4946936 (CC as reference) | |||||||||
| TC | 0.947 (0.849–1.056) | .328 | 0.941 (0.844–1.049) | .272 | 0.932 (0.819–1.060) | −0.071 (0.066) | .282 | ||
| TT | 0.807 (0.653–0.996) | .046 | 0.801 (0.649–0.989) | .04 | 0.657 (0.503–0.859) | −0.419 (0.136) | .002 | ||
| Residence (Rural as reference) | 0.854 (0.759–0.962) | .009 | 0.851 (0.756–0.957) | .007 | 0.805 (0.688–0.941) | −0.217 (0.08) | .007 | ||
| FOXO3_rs4946936 TC × residence—urban | 1.029 (0.808–1.311) | 0.028 (0.124) | .818 | ||||||
| FOXO3_rs4946936 TT × residence—urban | 1.846 (1.194–2.854) | 0.613 (0.222) | .006 | ||||||
| FOXO3_rs2802292 (TT as reference) | |||||||||
| TG | 0.956 (0.857–1.066) | .420 | 0.951 (0.853–1.061) | .371 | 0.958 (0.843–1.090) | −0.043 (0.066) | .517 | ||
| GG | 0.812 (0.670–0.985) | .034 | 0.806 (0.665–0.977) | .028 | 0.646 (0.506–0.825) | −0.437 (0.125) | <.001 | ||
| Residence (rural as reference) | 0.854 (0.759–0.962) | .009 | 0.851 (0.756–0.957) | .007 | 0.807 (0.686–0.95) | −0.214 (0.083) | .01 | ||
| FOXO3_rs2802292 TG × residence—urban | 0.970 (0.761–1.236) | −0.031 (0.124) | .805 | ||||||
| FOXO3_rs2802292 GG × residence—urban | 1.998 (1.342–2.975) | 0.692 (0.203) | .001 | ||||||
| FOXO3_rs2253310 (GG as reference) | |||||||||
| GC | 0.942 (0.845–1.051) | .285 | 0.938 (0.840–1.046) | .247 | 0.943 (0.829–1.073) | −0.058 (0.066) | .375 | ||
| CC | 0.808 (0.667–0.978) | .029 | 0.801 (0.661–0.97) | .023 | 0.643 (0.505–0.820) | −0.441 (0.124) | <.001 | ||
| Residence (rural as reference) | 0.854 (0.759–0.962) | .009 | 0.85 (0.755–0.957) | .007 | 0.805 (0.685–0.946) | −0.216 (0.082) | .009 | ||
| FOXO3_rs2253310 GC × residence—urban | 0.973 (0.763–1.241) | −0.027 (0.124) | .828 | ||||||
| FOXO3_rs2253310 CC × residence—urban | 1.996 (1.342–2.968) | 0.691 (0.202) | .001 |
Notes: HR = hazard ratio; CI = confidence interval; SNP = single-nucleotide polymorphism. All models adjusted for baseline age, sex, education, marriage, smoking, alcohol drinking, and exercise.