Table 1.
The effects of NET treatment in experimental models of sepsis.
| NET treatment | Sepsis model | Microbial Burden | Tissue Injury | Survival | Reference |
|---|---|---|---|---|---|
| DNase (NET digestion) | CLP | Increased | Increased | Reduced | Czaikoski et al. (78) Meng et al. (79) |
| DNase (NET digestion) | E.Coli IP infection | Increased | Decreased | – | McDonald et al. (84) |
| DNase (NET digestion) | MRSA IT infection | No effect | Decreased | Increased | Lafrancais et al. (95) |
| PAD4-/- (NET inhibition) | MRSA IT infection | Increased | Decreased | No effect | Lafrancais et al. (95) |
| Alcohol intoxication (NET inhibition) | CLP | Increased | – | Reduced | Jin et al. (82) |
| DNase (NET digestion) + Antibiotics | CLP | Reduced | Reduced | Increased | Czaikoski et al. (78) |
| Delayed DNase (NET digestion) | CLP | Reduced | Reduced | Increased | Mai et al. (98) |
| Disulfiram (NET inhibition) | CLP | – | Reduced | Increased | Silva et al. (91) |
| Cl-Amidine (NET inhibition) | CLP | – | – | Increased | Biron et al. (41) |
| DNase (NET digestion) | LPS | – | Reduced | Increased | Czaikoski et al. (78) |
| DNase (NET digestion) | LPS | – | Reduced | – | Liu et al. (85) |
- , ‘Not Studied’ ; CLP, Cecal Ligation Puncture; LPS, lipopolysaccharide; MRSA, Methicillin-resistant Staphilococcus aureus; E.coli, Escherichia Coli; PAD4, Peptidylarginine deiminase 4; IP, intra-peritoneal; IT, intra-tracheal.