TABLE 1.
Radionuclide Tracers for Imaging of Amyloidosis
| Tracer | Molecular target | Disease target |
| SPECT tracers | ||
| Bone-seeking radiotracers | Phosphate binders | ATTR |
| 99mTc-pyrophosphate | ||
| 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid | ||
| 99mTc-hydroxymethylene diphosphonate | ||
| Other radiotracers | ||
| 123I-serum amyloid protein | Serum amyloid P | All amyloidoses |
| 123I-aprotinin | Serum protease inhibitor, amyloid binder | All amyloidoses |
| PET tracers | ||
| Thioflavin-T derivatives | All amyloid fibrils (β-structure and side chains) | AL and ATTR |
| 18F-florbetapir | ||
| 18F-florbetaben | ||
| 18F-flutemetamol | ||
| 11C-Pittsburgh compound B | ||
| 18F-sodium fluoride | Microcalcification | ATTR |
| 124I-m11-1F4 monoclonal antibody | Immunoglobulin ALs | AL |