TABLE 3.
Site | Current study | FDA package insert (1) | Jones 1982 (21) | Mejia 1991 (22) | Deloar 1998 (23) | Hays 2002 (24) | Khamwan 2010 (25) | Velasques2010 (26) | Mattsson 2015 (27) |
n | 9 | Unknown | 11 | 8 | 6 | Unknown | 35 | 97 | Unknown |
Adrenals | 1.02E−02 ± 4.65E−03 | 1.3E−02* | 1.8E−02* | 1.6E−02* | 1.2E−02* | ||||
Brain | 4.20E−02 ± 8.91E−03 | 1.9E−02 | 2.2E−02 | 2.9E−02 | 3.7E−02 | 3.5E−02 | 4.6E−02* | 3.8E−02 | |
Breasts | 8.84E−03 ± 8.24E−04 | 9.2E−03* | 1.0E−02* | 1.0E−02* | 7.3E−03 | 7.7E−03 | 8.8E−03 | ||
Gallbladder wall | 1.33E−02 ± 1.40E−03 | 1.3E−02 | 1.3E−02 | ||||||
LLI wall | 1.44E−02 ± 1.66E−03 | 1.4E−02 | 1.8E−02* | 1.5E−02* | 1.4E−02 | ||||
Small intestine | 1.35E−02 ± 1.32E−03 | 1.3E−02 | 1.7E−02* | 1.5E−02* | 1.2E−02 | ||||
Stomach wall | 1.42E−02 ± 1.32E−03 | 1.3E−02 | 1.5E−02* | 1.2E−02 | 1.2E−02 | 1.1E−02 | |||
ULI wall | 1.33E−02 ± 1.58E−03 | 1.2E−02 | 1.7E−02* | 1.5E−02* | 1.2E−02 | ||||
Heart wall | 3.28E−02 ± 1.57E−02 | 5.9E−02* | 4.3E−02* | 4.5E−02* | 1.7E−02 | 3.5E−02* | 6.9E−02* | 6.7E−02* | |
Kidneys | 2.29E−02 ± 5.11E−03 | 2.0E−02 | 2.3E−02* | 3.0E−02* | 2.8E−02* | 5.9E−03 | 2.7E−02* | 7.4E−02* | 1.7E−02 |
Liver | 1.50E−02 ± 1.98E−03 | 1.6E−02* | 2.0E−02* | 2.3E−02* | 1.8E−02* | 8.4E−03 | 3.0E−02* | 2.4E−02* | 2.1E−02* |
Lungs | 1.38E−02 ± 3.31E−03 | 1.7E−02* | 2.1E−02* | 1.1E−02 | 1.8E−02* | 8.4E−03 | 4.6E−03 | 1.5E−02* | 2.0E−02* |
Muscle | 8.89E−03 ± 1.24E−03 | 1.1E−02* | 1.0E−02* | ||||||
Ovaries | 1.13E−02 ± 3.21E−04 | 1.4E−02* | 1.4E−02* | 1.6E−02* | 1.5E−03* | 1.1E−02 | 1.4E−02* | ||
Pancreas | 1.40E−02 ± 4.08E−03 | 2.6E−02* | 2.0E−02* | 2.6E−02* | 1.6E−03 | 1.3E−02 | |||
Red marrow | 8.74E−03 ± 1.15E−03 | 1.3E−02* | 1.4E−02* | 1.2E−02* | 5.6E−03 | 1.7E−03 | 1.8E−02* | 1.1E−02* | 1.1E−02* |
Osteogenic cells | 1.39E−02 ± 2.37E−03 | 4.1E−02* | 1.5E−02* | 8.0E−03 | 2.1E−02* | 1.1E−02 | 1.1E−02 | ||
Skin | 6.90E−03 ± 1.01E−03 | 8.1E−03* | 1.1E−03 | 7.8E−03* | |||||
Spleen | 1.35E−02 ± 3.45E−03 | 3.8E−02* | 4.3E−02* | 2.2E−02* | 1.4E−02* | 2.1E−03 | 1.5E−02* | 1.1E−02 | |
Testes | 8.63E−03 ± 2.55E−03 | 1.1E−02* | 1.8E−02* | 1.5E−02* | 1.5E−02* | 1.5E−03 | 1.1E−02* | 1.1E−02* | 1.1E−02* |
Thymus | 9.72E−03 ± 1.76E−03 | 1.2E−02* | 1.2E−02* | 1.2E−02* | |||||
Thyroid | 9.99E−03 ± 3.12E−03 | 1.1E−02* | 1.3E−02* | 1.3E−02* | 1.0E−02* | 1.0E−02* | 1.0E−02* | ||
Bladder wall | 8.46E−02 ± 1.42E−02 | 8.6E−02* | 1.2E−01* | 1.2E−01* | 3.1E−01* | 4.3E−02 | 6.4E−02 | 1.3E−01 | |
Uterus | 2.98E−02 ± 8.18E−03 | 1.7E−02 | 1.9E−02 | 1.9E−02 | 1.8E−02 | ||||
Total body | 1.03E−02 ± 1.44E−03 | 1.1E−02* | 1.2E−02* | 1.4E−02* | |||||
Effective dose (mSv/MBq) | 1.53E−02 ± 1.63E−03 | 1.8E−02* | 2.4E−02* | 2.9E−02* | 1.5E−02 | 1.9E−02* |
Higher reported dose than in current study.
FDA = Food and Drug Administration; LLI = lower large intestine; ULI = upper large intestine.
All dose estimates are reported in mSv/MBq.