Table 1.
Comparison of pregnancies to SLE cases and controls
| Characteristics | Pregnancies to SLE cases | Pregnancies to controls | P value |
|---|---|---|---|
| (n = 255) a | (n = 604) a | ||
| Mean age at delivery ± SD (y) | 27.3 ± 6.0 | 27.0 ± 6.6 | P = 0.67 |
| Race (%) | |||
| White | 66% | 59% | P = 0.11 |
| African American | 30% | 38% | |
| Asian | 2% | 2% | |
| Other/Multi‐race | 2% | 1% | |
| Ethnicity (%) | |||
| Hispanic | 5% | 11% | P < 0.01 |
| Mean duration in the EHR (y) ± SD | 13.3 ± 8.3 | 12.0 ± 7.6 | P = 0.18 |
| Parity | |||
| Mean number of pregnancies per mother ± SD | 2.3 ± 1.6 | 3.1 ± 2.0 | P < 0.001 |
| Mean number of deliveries per mother ± SD | 1.7 ± 0.9 | 2.3 ± 1.3 | P = 0.001 |
| Pregnancy outcomes | |||
| Live birth (%) | 82% (194/238) | 83% (502/602) | P = 0.72 |
| Cesarean section (%) | 47% (97/207) | 31% (168/546) | <0.001 |
| Mean gestational age ± SD (wk) | 32.9 ± 8.2 | 35.0 ± 9.8 | <0.001 |
| Mean birthweight ± SD (kg) | 2.5 ± 1.0 | 3.2 ± 0.7 | <0.001 |
| Mean Apgar score at 1 min ± SD | 7.1 ± 2.3 | 7.9 ± 1.3 | 0.07 |
| Mean Apgar score at 5 min ± SD | 8.3 ± 1.5 | 8.8 ± 0.7 | 0.01 |
| Preterm (%) | 47% (90/191) | 14% (71/497) | <0.001 |
| Preeclampsia (%) | 23% (45/199) | 9% (32/368) | <0.001 |
| Preeclampsia occurring preterm (%) | 84% (38/45) | 28% (9/32) | <0.001 |
Abbreviations: EHR, electronic health record; SLE, systemic lupus erythematosus.
a
N refers to number of pregnancies. For SLE cases, there were 255 pregnancies to 174 mothers with SLE. For controls, there were 602 pregnancies to 224 control mothers.