Table 3.
Clinical Trials Testing BMS-986205 in Oncological Indications
| Phase | Indication | Co-Therapy | Estimated or Actual Enrollment | Identifier | Status |
|---|---|---|---|---|---|
| Phase I | Multiple Malignancies | Itraconazole, Rifampin | 53 | NCT03346837 | Completed in December 2017 |
| Phase I | Advanced Cancer | Nivolumab | 11 | NCT03192943 | Completed in December 2018 |
| Phase I | Glioblastoma | Nivolumab, Radiation, Temozolomide | 30 | NCT04047706 | Recruiting |
| Phase I | Advanced Cancer | Nivolumab, Relatlimab, Cabiralizumab, Ipilimumab, Radiotherapy | 50 | NCT03335540 | Recruiting |
| Phase I/II | Malignant Solid Tumor | Nivolumab | 17 | NCT03792750 | Completed in October 2021 |
| Phase I/II | Hepatic Cell Carcinoma | Nivolumab | 8 | NCT03695250 | Active, not recruiting |
| Phase I/II | Advanced bladder cancer | Nivolumab, Ipilimumab | 516 | NCT02658890 | Active, not recruiting |
| Phase I/II | Advanced Cancer | Nivolumab, Ipilimumab, Relatlimab | 184 | NCT03459222 | Recruiting |
| Phase II | NSCLC | Nivolumab, Ipilimumab, Relatlimab, Dasatinib | 295 | NCT02750514 | Terminated in January 2020 |
| Phase II | Bladder Cancer | Nivolumab, BCG | 69 | NCT03519256 | Active, not recruiting |
| Phase II | Endometrial Cancer | Nivolumab | 24 | NCT04106414 | Active, not recruiting |
| Phase II | Squamous Cell Carcinoma of the Head and Neck | Nivolumab | 48 | NCT03854032 | Recruiting |
| Phase II | Renal Cell Carcinoma | Nivolumab, Ipilimumab, Relatlimab, BMS-813160 | 200 | NCT02996110 | Recruiting |
| Phase II | Gastric Cancer | Nivolumab, Ipilimumab, Relatlimab, Rucaparib | 186 | NCT02935634 | Active, not recruiting |
| Phase II | Melanoma | Nivolumab, Ipilimumab | 0 | NCT04007588 | Withdraw |
| Phase III | Advanced Melanoma | Nivolumab | 20 | NCT03329846 | Completed in July 2020 |
| Phase III | Bladder Cancer | Nivolumab, Gemcitabine, Cisplatin | 976 | NCT03661320 | Recruiting |
| Phase III | Head and neck cancer | Nivolumab, Cetuximab, Chemotherapy | 0 | NCT03386838 | Withdraw |
| Phase III | NSCLC | Nivolumab, Chemotherapy | 0 | NCT03417037 | Withdraw |
Note: The data were obtained from ClinicalTrials.gov database (https://www.clinicaltrials.gov).