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. 2022 Jul 29;13:954007. doi: 10.3389/fimmu.2022.954007

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Copyright © 2022 Sanges, Guerrier, Duhamel, Guilbert, Hauspie, Largy, Balden, Podevin, Lefèvre, Jendoubi, Speca, Hachulla, Sobanski, Dubucquoi and Launay

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Serum levels of soluble markers of B cell activation in SSc patients and healthy controls (discovery cohort). APRIL, a proliferation-inducing ligand; BAFF, B-cell-activating factor; BCMA, B-cell maturation antigen; CD, cluster of differentiation; CXCL13, C-X-C motif chemokine 13; HC, healthy controls; Ig, immunoglobulin; RF, rheumatoid factor; s, soluble; SSc, systemic sclerosis; TACI, transmembrane activator and CAML interactor. The dotted line on the RF panel represents the threshold for RF positivity. Error bars display means and standard deviations. p-values are adjusted for age, gender and multiplicity. The p-value displayed on the RF panel refers to the analysis using RF as a binary variable.