Table 8.

Synthetic view of the associations identified between soluble markers of B cell activation and clinical markers of PH in the discovery and validation cohorts.

Discovery cohort		Validation cohort
PH vs no PH	IgG RF	PAH vs no PAH	IgG β2-microglobulin sBCMA sCD23 sCD27
Nt-pro-BNP	β2-microglobulin sBCMA	Nt-pro-BNP	BAFF
Peak TRV	BAFF RF	Peak TRV	BAFF IgM
DLCO	β2-microglobulin BAFF sCD23 RF	FVC/DLCO	β2-microglobulin BAFF IgG

BAFF, B-cell-activating factor; BCMA, B-cell maturation antigen; CD, cluster of differentiation; DLCO, diffusing capacity of the lung for carbon monoxide; Nt-pro-BNP, N-terminal prohormone of brain natriuretic peptide; PAH, pulmonary arterial hypertension; PH, pulmonary hypertension; RF, rheumatoid factor; s, soluble; TRV, tricuspid regurgitation velocity.

Bold characters denote statistical significance (p< 0.05). Regular characters denote trends for statistical significance (p< 0.10).