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. 2022 Jul 29;9:918359. doi: 10.3389/fcvm.2022.918359

TABLE 5.

Univariate and multivariate logistic regression analyses for high GS.

Variables Univariate
p-value Multivariate
p-value
OR 95% CI OR 95% CI
Age (years) 1.01 0.99–1.02 0.560
Male, n (%) 1.40 0.97–2.01 0.069 1.39 0.94–2.06 0.097
LVEF (%) 0.48 0.10–2.23 0.347
SBP (mmHg) 1.00 0.99–1.01 0.559
DBP (mmHg) 1.00 0.98–1.01 0.614
Current smoking 0.89 0.52–1.53 0.664
FH-CAD 3.29 2.32–4.67 <0.001 3.21 2.24–4.61 <0.001
Glucose metabolism status
 NGR Reference Reference
 PDM 1.33 0.82–2.16 0.246 1.16 0.68–1.97 0.583
 DM 1.85 1.29–2.67 0.001 1.65 0.89–3.04 0.113
Hypertension 0.90 0.64–1.26 0.537
TC (mg/dL) 1.00 1.00–1.01 0.356
LDL-C (mg/dL) 1.01 1.00–1.01 0.028 1.01 1.00–1.01 0.031
eGFR (mL/min/1.73 m2) 1.00 0.99–1.01 0.941
UA (μmol/L) 1.00 1.00–1.00 0.500
Single antiplatelet therapy 0.89 0.59–1.33 0.561
Dual antiplatelet therapy 3.59 1.39–9.25 0.008 3.77 1.37–10.40 0.010
Beta-blocker 0.77 0.39–1.52 0.444
ACEI/ARB 0.90 0.50–1.60 0.710
Statin 0.77 0.50–1.19 0.234
Insulin 1.63 1.05–2.52 0.029 1.21 0.66–2.24 0.537
Metformin 0.98 0.57–1.68 0.942
Other hypoglycemic drugs 1.64 1.07–2.51 0.023 0.89 0.48–1.64 0.703
TG/HDL-C ratio 1.13 0.97–1.32 0.113
TyG index 1.15 0.98–1.35 0.091
METS-IR 1.32 1.12–1.55 0.001 1.22 1.02–1.47 0.032

p-values in bold are <0.05.

OR, odds ratio; CI, confidence interval; SBP, systolic blood pressure; DBP, diastolic blood pressure; LVEF, left ventricular ejection fraction; FH-CAD, family history of coronary artery disease; NGR, normal glucose regulation; PDM, prediabetes mellitus; DM, diabetes mellitus; FPG, fasting plasma glucose; TC, total cholesterol; TG, triglyceride; LDL-C, low-density lipoprotein-cholesterol; HDL-C, high-density lipoprotein-cholesterol; eGFR, estimated glomerular filtration rate; UA, uric acid; ACEI, angiotensin-converting enzyme inhibitors; ARB, angiotensin receptor blockers; TG/HDL-C ratio, the ratio of triglycerides to high-density lipoprotein cholesterol; TyG index, triglyceride and glucose index; METS-IR, metabolic score for insulin resistance.