Table 2.
OS of HCC at different RNF125 levels.
| Clinicopathological index | Subgroup | Cut off | Grouping (cases) | Median OS (months) | HR value | P value | |||
|---|---|---|---|---|---|---|---|---|---|
| LEG | HEG | LEG | HEG | ||||||
| Entire queue | 182 | 122 | 242 | 31 | 70.5 | 0.57 (0.4-0.81) | 1.50E-03 | ||
| Stage | Stage 1 | 367 | 82 | 88 | 56.5 | 84.4 | 0.46 (0.24-0.86) | 0.013 | |
| Stage 2 | 164 | 27 | 56 | 28.3 | 13.8 | 0.5 (0.23-1.08) | 0.0724 | ||
| Stage 3 | 323 | 48 | 35 | 14 | 40.3 | 0.49 (0.26-0.92) | 0.024 | ||
| Grade | Grade 1 | 313 | 17 | 38 | 10 | 47.4 | 0.54 (0.2-1.43) | 0.21 | |
| Grade 2 | 195 | 50 | 124 | 25.6 | 81.9 | 0.51 (0.3-0.86) | 0.011 | ||
| Grade 3 | 358 | 78 | 40 | 13.7 | 22 | 0.45 (0.22-0.94) | 0.029 | ||
| Vascular invasion | None | 171 | 54 | 149 | 37.8 | 81.9 | 0.61 (0.36-1.05) | 0.072 | |
| Micro | 110 | 21 | 69 | 82.9 | 108.6 | 0.57 (0.25-1.32) | 0.1831 | ||
| Gender | Male | 367 | 139 | 107 | 42.4 | 84.7 | 0.43 (0.27-0.71) | 6.00E-04 | |
| Female | 184 | 42 | 76 | 37.8 | 56.5 | 0.74(0.42-1.3) | 0.2917 | ||
| Race | White | 207 | 54 | 127 | 37.8 | 54.1 | 0.67(0.42-1.07) | 0.0905 | |
| Asian | 341 | 91 | 64 | NA | NA | 0.26(0.12-0.56) | 2.00E-04 | ||
| Sorafenib treatment | 196 | 9 | 20 | 21.1 | 45.7 | 0.17(0.05-0.62) | 0.0002 | ||
| Alcohol consumption | Yes | 362 | 60 | 55 | 41 | 70.5 | 0.4(0.21-0.78) | 0.0052 | |
| None | 171 | 71 | 131 | 30 | 71 | 0.55(0.35-0.87) | 0.0091 | ||
| Hepatitis virus | Yes | 174 | 49 | 101 | 14.2 | 54.1 | 0.49(0.25-0.93) | 0.0249 | |
| None | 312 | 85 | 82 | 21.4 | 70.5 | 0.46(0.29-0.74) | 1.00E-03 | ||
Micro, microvascular invasion.
LEG: The RNF125 low expression group distinguished by cutoff values.
HEG: The RNF125 high expression group distinguished by cutoff values.