Table II.
Compositions of DPI Suggested by Box Behnken Design, Corresponding Responses and Related Parameters
| Run | A: Flow rate (ml/min) | B: Aspiration (%) | C: Concentration (% w/v) | Response 1: Vd (µm) | Response 2: MMAD (µm) | Bulk Density (g/cc) | Tapped Density (g/cc) | Carr’s Index |
|---|---|---|---|---|---|---|---|---|
| 1 | 1.00 | 65.00 | 5.00 | 3.903 | 2.81 | 0.2585 | 0.517 | 50 |
| 2 | 3.00 | 65.00 | 3.00 | 8.914 | 5.47 | 0.250 | 0.376 | 33.51 |
| 3 | 5.00 | 65.00 | 5.00 | 11.829 | 6.85 | 0.1796 | 0.335 | 46.38 |
| 4 | 3.00 | 65.00 | 3.00 | 12.065 | 7.13 | 0.2617 | 0.349 | 25.01 |
| 5 | 5.00 | 80.00 | 3.00 | 10.84 | 6.30 | 0.2202 | 0.3376 | 34.77 |
| 6 | 3.00 | 80.00 | 1.00 | 11.648 | 8.54 | 0.2552 | 0.538 | 52.56 |
| 7 | 3.00 | 50.00 | 1.00 | 16.223 | 7.36 | 0.1108 | 0.2056 | 46.10 |
| 8 | 3.00 | 50.00 | 5.00 | 10.38 | 6.22 | 0.2512 | 0.3589 | 30.00 |
| 9 | 3.00 | 65.00 | 3.00 | 11.026 | 6.86 | 0.2193 | 0.388 | 43.47 |
| 10 | 3.00 | 65.00 | 3.00 | 10.515 | 6.28 | 0.2497 | 0.3567 | 29.99 |
| 11 | 1.00 | 65.00 | 1.00 | 11.33 | 6.80 | 0.2295 | 0.3607 | 36.37 |
| 12 | 5.00 | 65.00 | 1.00 | 11.181 | 5.50 | 0.1539 | 0.2419 | 36.37 |
| 13 | 1.00 | 50.00 | 3.00 | 10.579 | 6.82 | 0.262 | 0.415 | 36.86 |
| 14 | 3.00 | 65.00 | 3.00 | 11.229 | 6.28 | 0.238 | 0.3125 | 23.84 |
| 15 | 3.00 | 80.00 | 5.00 | 13.001 | 8.08 | 0.2512 | 0.3865 | 35.00 |
| 16 | 5.00 | 50.00 | 3.00 | 14.369 | 5.26 | 0.0704 | 0.1342 | 47.54 |
| 17 | 1.00 | 80.00 | 3.00 | 14.915 | 9.34 | 0.2684 | 0.3923 | 31.58 |