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. Author manuscript; available in PMC: 2022 Aug 12.
Published in final edited form as: Cell Rep. 2022 Jul 19;40(3):111104. doi: 10.1016/j.celrep.2022.111104

Figure 2. Mutant KRAS signaling mediates epigenomic reprogramming of ISGs.

Figure 2.

(A) Mean ATAC-seq counts per million (CPM) (95% confidence interval [CI]) in promoter regions of upregulated ISGs (log2 fold change >1.5) in both mutant KRAS and control (CTRL) AALEs.

(B) Differential expression of ISGs with unique peaks near TSS (only present in mutant KRAS or control AALEs).

(C) ATAC-seq coverage in both mutant KRAS and CTRL AALEs for subset of ISGs with unique peaks detected near TSS.

(D) Significant Gene Ontology (GO) term enrichment over unique peaks detected in mutant KRAS AALEs as determined by genomic regions enrichment of annotations tool (GREAT) analysis.