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. Author manuscript; available in PMC: 2022 Aug 12.
Published in final edited form as: Cell Rep. 2022 Jul 19;40(3):111104. doi: 10.1016/j.celrep.2022.111104

Figure 5. Broad downregulation of KZNFs in mutant KRAS LUAD in vivo.

Figure 5.

(A) Hierarchical clustering of expression Z scores in TCGA LUAD RNA-seq data for KZNF genes downregulated in mutant KRAS AALEs; KZNFs with unique peaks in their promoter regions in control AALEs are labeled.

(B) Distribution of Z scores for significantly downregulated KZNF genes (Wilcox) in TCGA LUAD RNA-seq data.

(C) Kaplan-Meier survival curve for patients in the TCGA LUAD dataset stratified into thirds by expression levels of KZNFs downregulated in mutant KRAS AALEs.

(D) Model of mutant KRAS-mediated regulation of TE RNAs and ISGs by KZNFs. Created with BioRender.com.