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. 2022 Aug 12;8(31):eabo6049. doi: 10.1126/sciadv.abo6049

Fig. 7. Proposed model for the function of C11orf94 in the testis.

Fig. 7.

Within round spermatids, C11orf94 binds to the catalytic center of SPPL2c, which protects it from degradation by a yet unknown mechanism. Izumo1 is recruited to the C11orf94-SPPL2c complex, which results in retention of the fusion factor within the ER. The C11orf94/SPPL2c/Izumo1 complex serves as platform for recruitment of several Izumo1-interacting proteins including ACE3 but potentially also other fusion-relevant molecules. Last, interaction with these proteins leads to ER export of Izumo1 complexes.