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. 2022 Aug 15;132(16):e155931. doi: 10.1172/JCI155931

Figure 5. Repeat RNAs enriched in tumor cell–derived extracellular vesicles can induce changes in the tumor immune microenvironment.

Figure 5

(A) Pearson’s correlation coefficients between normalized HSATII expression and the relative frequency of immune cell types in 96 human early-stage ovarian carcinoma tumor samples as identified by the xCell algorithm. Red asterisks indicate correlations with Q < 0.1. *P < 0.05. (B) RNA content of tumor cells (C) and tumor cell–derived extracellular vesicles (E) in PDAC (top) and EOC (bottom) cell lines, as determined by total RNA-Seq and plotted as a fraction of the total transcriptome. (C) Expression heatmap of representative repetitive elements in extracellular vesicles released by EOC cell lines.