Table 2.
Genetic association study of IFNAR2 variants with mortality in patients with severe COVID-19.
| IFNAR2 single-nucleotide variant | All, n = 1202 | Non-survivors, n = 426 | Survivors, n = 776 | p | OR (CI 95%) | FDRb | |
|---|---|---|---|---|---|---|---|
| rs2834158 | |||||||
|
TT
TC CC |
412 (0.343) 563 (0.468) 227 (0.189) |
126 (0.296) 209 (0.490) 91 (0.214) |
286 (0.368) 354 (0.456) 136 (0.175) |
0.029 | 1 (reference) 1.34 (1.02-1.75) 1.51 (1.08-2.13) |
0.072 | |
|
T
C |
1,387 (0.577) 1,017 (0.423) |
461 (0.541) 391 (0.459) |
926 (0.597) 626 (0.403) |
0.008 | 1.25 (1.06-1.48) | 0.029 | |
| rs2236757a | |||||||
|
AA
AG GG |
396 (0.330) 541 (0.450) 265 (0.220 |
119 (0.280) 205 (0.481) 102 (0.239) |
277 (0.356) 336 (0.433) 163 (0.210) |
0.023 | 1 (reference) 1.42 (1.07-1.87) 1.45 (1.04-2.02) |
0.116 | |
|
A
G |
1,333 (0.554) 1,071 (0.446) |
443 (0.520) 409 (0.480) |
890 (0.573) 662 (0.427) |
0.012 | 1.24 (1.05-1.47) | 0.029 | |
| rs3153 | |||||||
|
AA
AG GG |
400 (0.333) 564 (0.469) 238 (0.198) |
122 (0.286) 212 (0.498)) 92 (0.216) |
278 (0.358) 352 (0.454) 146 (0.188) |
0.039 | 1 (reference) 1.37 (1.04-1.80) 1.43 (1.02-2.01) |
0.065 | |
|
A
G |
1,364 (0.567) 1,040 (0.433) |
456 (0.535) 396 (0.465) |
908 (0.585) 644 (0.415) |
0.018 | 1.22 (1.03-1.45) | 0.030 | |
| rs1051393 | |||||||
|
GG
GT TT |
389 (0.324) 578 (0.481) 235 (0.195) |
122 (0.286) 212 (0.498) 92 (0.216) |
267 (0.344) 366 (0.472) 143 (0.184) |
0.099 | NA | 0.124 | |
|
G
T |
1,356 (0.564) 1,048 (0.436) |
456(0.535) 396 (0.465) |
900 (0.580) 652 (0.420) |
0.035 | 1.20 (1.01-1.42) | 0.043 | |
| rs2229207 | |||||||
|
TT
TC CC |
811 (0.675) 348 (0.289) 43 (0.036) |
286 (0.671) 125 (0.293) 15 (0.035) |
525 (0.677) 223 (0.287) 28 (0.036) |
0.974 | NA | 0.974 | |
|
T
C |
1,970 (0.819) 434 (0.181) |
697 (0.818) 155 (0.182) |
1,273 (0.820) 279 (0.180) |
0.895 | NA | 0.895 | |
aDeviation from Hardy-Weinberg Equilibrium p<0.01; bBenjamini-Hochberg method. CI, confidence interval; FDR, false discovery rate; NA, does not apply; OR, odds ratio.