Table 3.
Unadjusted primary and secondary outcomes according to pre-admission anticoagulant use
| Total (N = 630) | Anticoagulation |
p Value | ||
|---|---|---|---|---|
| Yes (N = 361) | No (N = 269) | |||
| Composite of all-cause mortality and arterial or venous thrombosis | 224 (35.6%) | 98 (27.1%) | 126 (46.8%) | < 0.001 |
| All-cause mortality | 126 (20.0%) | 59 (16.3%) | 67 (24.9%) | 0.007 |
| Composite arterial or venous thrombosis | 135 (21.4%) | 53 (14.7%) | 82 (30.5%) | < 0.001 |
| Venous thromboembolism | 55 (8.7%) | 14 (3.9%) | 41 (15.2%) | <0.001 |
| Acute DVT | 28 (4.4%) | 7 (1.9%) | 21 (7.8%) | < 0.001 |
| Acute pulmonary embolism | 31 (4.9%) | 8 (2.2%) | 23 (8.6%) | < 0.001 |
| Arterial thrombosis | 91 (14.4%) | 42 (11.6%) | 49 (18.2%) | 0.020 |
| Acute coronary syndrome | 52 (8.3%) | 25 (6.9%) | 27 (10.0%) | 0.16 |
| TIA | 5 (0.8%) | 4 (1.1%) | 1 (0.4%) | 0.30 |
| Stroke | 36 (5.7%) | 16 (4.4%) | 20 (7.4%) | 0.11 |
| Acute limb ischemia | 6 (1.0%) | 3 (0.8%) | 3 (1.1%) | 0.72 |
| Acute mesenteric ischemia | 3 (0.5%) | 0 (0.0%) | 3 (1.1%) | 0.044 |
| ICU admission | 131 (20.8%) | 53 (14.7%) | 78 (29.0%) | < 0.001 |
| Intubation | 73 (11.6%) | 23 (6.4%) | 50 (18.6%) | < 0.001 |
| Non-invasive ventilation | 141 (22.4%) | 67 (18.6%) | 74 (27.5%) | 0.007 |
| Supplemental oxygen requirement | 486 (77.1%) | 271 (75.1%) | 215 (79.9%) | 0.15 |
| Cardiac arrest | 23 (3.7%) | 9 (2.5%) | 14 (5.2%) | 0.07 |
| Red blood cell transfusion | 65 (10.3%) | 30 (8.3%) | 35 (13.0%) | 0.055 |
| Major bleed | 94 (14.9%) | 47 (13.0%) | 47 (17.5%) | 0.12 |
| Length of stay – days | 7.0 (4.0, 12.0) | 6.0 (3.0, 11.0) | 7.0 (4.0, 14.0) | < 0.001 |
ICU = Intensive care unit; DVT = deep vein thrombosis; TIA = transient ischemic attack.
Values are n (%) or median (IQR).