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. 2022 Jul 7;41(33):3979–3990. doi: 10.1038/s41388-022-02386-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A CircME1 expression levels in different ccRCC cell lines and immortalized proximal tubule epithelial cells (HK2). B CircME1 was silenced in 786-O and Caki-1 cells using two different shRNAs (left panel) and overexpressed in 769-P cells (right panel). CCK8 and colony formation assays showing that the proliferation and colony formation of ccRCC cells were suppressed by circME1 knockdown (C, E), but promoted by circME1 overexpression (D, F). *p < 0.05, **p < 0.01, and ***p < 0.001.