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. 2022 Jul 7;41(33):3979–3990. doi: 10.1038/s41388-022-02386-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A qPCR results showed that the mRNA level of ME1 was decreased after knockdown of circME1 and increased after overexpression of circME1. B Western blot analysis showed that knockdown and overexpression of circME1 changed the protein level of ME1. C IHC analysis showed that the ME1 protein level was remarkably reduced in xenografts generated from circME1-silencing cells. D The schematic diagram of ME1 in glucose metabolism. ***p < 0.001.