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. 2022 Jul 7;41(33):3979–3990. doi: 10.1038/s41388-022-02386-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — The relative glucose uptake of ccRCC cells was inhibited by knockdown of circME1 (A) and promoted by overexpression of circME1 (B). C, D Knockdown of circME1 markedly impaired glycolysis and glycolytic capacity of ccRCC cells, while overexpression of circME1 enhanced them. ECAR was measured using the Seahorse analyzer. Glucose, oligomycin and 2-DG were sequentially injected at the indicated time points. E, F Knockdown of circME1 increased OCR, while overexpression of circME1 decreased it. G Knockdown of circME1 remarkably decreased the key glycolytic enzymes while overexpression of circME1 significantly increased the expression of these glycolytic enzymes in ccRCC cells. *p < 0.05, **p < 0.01, ***p < 0.001.