Table 1.

Univariate and multivariate Cox regression analyses of potential prognostic factors for overall survival in patients with OSCC (n = 89)

Characteristics	n	Univariate analysis	Multivariate analysis	p value
		Log-lank p value	Hazard ratio (95% CI)
Age (years)
≤ 65	34	0.491	ND	ND
> 65	55
Gender
Male	53	0.112	ND	ND
Female	36
Primary site
Tongue	37	0.545	ND	ND
Mandible	24
Oral floor	11
Buccal mucosa	10
Maxilla	7
Clinical T category
T1, T2	44	0.458	ND	ND
T3, T4	45
Clinical N category
N0	27	0.959	ND	ND
N ≥ 1	62
Pathological T category
T1, T2	46	0.300	ND	ND
T3, T4	43
Pathological N category
N0	50	0.071	1.795 (0.818–4.068)	0.144
N ≥ 1	39
Differentiation
Well	51	0.468	ND	ND
Poor, moderate	38
CD8+ cells/mm2 in the tumor
> 1588	41	0.864	ND	ND
≤ 1588	48
CD169 score
High	61	0.002*	3.009 (1.374–6.692)	0.006*
Low	28

OSCC, oral squamous cell carcinoma; CI, confidence interval; ND, not done; LN, lymph node. The average number of CD8⁺cells/mm²in the tumor was 1588

*Statistically significant results