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. 2022 Aug 12;12:13757. doi: 10.1038/s41598-022-17450-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Knockdown of circADAMTS6 inhibits the ability of cell proliferation, migration and invasion in ESCC cells and tumor formation in vivo. (A) Relative expression level of circADAMTS6 transfected with si-NC and si-circADAMTS6 in KYSE150 cell. (B, C) Cell proliferation was assessed by CCK8 and colony formation assay after down-regulation of circADAMTS6. (D) Representative photographs and tumor growth curves of subcutaneous xenograft tumor model developed from KYSE150 cell with si-NC and si-circADAMTS6 (n = 6). The tumor volumes were calculated according to the formula (L × W²)/2. (E, F) Knockdown circADAMTS6 repressed migration and invasion of ESCC cells. (*P < 0.05, **P < 0.01, ***P < 0.001).