Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Aug 12;12:13757. doi: 10.1038/s41598-022-17450-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

(A) Kaplan–Meier survival analysis indicated that circADAMTS6 high expression (P < 0.001) was significantly associated with shorter overall survival in ESCC cases. (B) CircADAMTS6 and AGR2 expression were measured after transfection of si-circADAMTS6 and co-transfection of AGR2 and circADAMTS6 by qRT-PCR. (C) Western blot analysis revealed that AGR2 and YAP proteins were significantly decreased after knockdown of circADAMTS6, while pYAP protein was significantly increased. (D–G) Rescue assays showed that transfection of AGR2 reversed the suppression of the proliferation (D, E), migration and invasion (F, G) caused by circADAMTS6 silencing in KYSE150 cell. (H) Western blot validated that the effect of pYAP, YAP and AGR2 proteins caused by si-circADAMTS6 could be rescued by transfection of AGR2.